An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

Toshiyasu Inuzuka, Keita Yamamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Yoshinori Kawazoe, Daisuke Uemura

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.

本文言語English
ページ(範囲)6711-6714
ページ数4
ジャーナルTetrahedron Letters
55
49
DOI
出版ステータスPublished - 2014 12月 3

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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