TY - JOUR
T1 - An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region
AU - Osoegawa, Kazutoyo
AU - Susukida, Rie
AU - Okano, Saishi
AU - Kudoh, Jun
AU - Minoshima, Shinsei
AU - Shimizu, Nobuyoshi
AU - De Jong, Pieter J.
AU - Groet, Juergen
AU - Ives, Jane
AU - Lehrach, Hans
AU - Nizetic, Dean
AU - Soeda, Eiichi
N1 - Funding Information:
Also, we thank T. Shimokawa and H. Kishida for excellent technical assistance in the initial stage of this work. This work was accomplished under the auspices of RIKEN Project ``Human Genome Organization'' and was also supported by Special Coordination Funds of the Science and Technology Agency of the Japanese Government, a Grant-in-Aid for Creative Basic Research (Human Genome Program), Grant-in-Aid for Scienti®c Research from the Ministry of Education, Science and Culture of Japan, and partly by Grant GENO-CT93-0015 from the Commission of European Communities.
PY - 1996/3/15
Y1 - 1996/3/15
N2 - The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high- resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.
AB - The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high- resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.
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U2 - 10.1006/geno.1996.0132
DO - 10.1006/geno.1996.0132
M3 - Article
C2 - 8838801
AN - SCOPUS:0029913925
SN - 0888-7543
VL - 32
SP - 375
EP - 387
JO - Genomics
JF - Genomics
IS - 3
ER -