An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides

Seiya Katahara, Shoichiro Kobayashi, Kanami Fujita, Tsutomu Matsumoto, Takaaki Sato, Noritaka Chida

研究成果: Article査読

75 被引用数 (Scopus)

抄録

An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides was reported. The reaction took place through two types of iridium-catalyzed reactions including dehydrosilylation and hydrosilylation. The method showed high chemoselectivity in the presence of sensitive functional groups, such as methyl esters, and was successfully applied to the synthesis of cyclic and macrocyclic nitrones, which are known to be challenging compounds to access by conventional methods. 1H NMR studies strongly supported generation of an N-siloxyamide and an N,O-acetal as the actual intermediates.

本文言語English
ページ(範囲)5246-5249
ページ数4
ジャーナルJournal of the American Chemical Society
138
16
DOI
出版ステータスPublished - 2016 4 27

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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