An Optimized and General Synthetic Strategy To Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides

Taejung Kim, Kyu Hyuk Jeong, Ki Sung Kang, Masaya Nakata, Jungyeob Ham

研究成果: Article査読

18 被引用数 (Scopus)

抄録

A simple method for the preparation of arylnaphthalene lactone natural products was developed and used to synthesize diphyllin (10), justicidin A (12), cilinaphthalide B (13), taiwanin E (15), chinensinaphthol (16), taiwanin E methyl ether (17), chinensinaphthol methyl ether (18), justicidin C (21), and justicidin D (22). Key steps of the syntheses include the Hauser–Kraus annulation of cyanophthalides 7a and 7b and Suzuki–Miyaura cross-coupling reactions between arylnaphthalene lactones that contain a sulfonate group (i.e., 9, 14, 19, and 20) and various potassium aryltrifluoroborates.

本文言語English
ページ(範囲)1704-1712
ページ数9
ジャーナルEuropean Journal of Organic Chemistry
2017
13
DOI
出版ステータスPublished - 2017 4月 3

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

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