Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

T. Sato, H. Nishi, Y. Okahata, Y. Shoji, J. Shimada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

本文言語English
ページ(範囲)303-304
ページ数2
ジャーナルNucleic acids symposium series
37
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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