Analysis of C-KIT, TIE and HTK expression on leukemic cells using flow cytometry: A preliminary report

Kazuo Muroi, Toshio Suda, Chizuru Kawano, Youichi Amemiya, Mitsuoki Eguchi, Yasusada Miura, Keiya Ozawa

研究成果: Article

8 引用 (Scopus)

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C-KIT, TIE and HKT expression on leukemic cells from patients were simultaneously analyzed using flow cytometry. Consistent with previous reports, leukemic cells from most patients with de novo acute myeloid leukemia (AML) were C-KIT-positive (28/35), while those from patients with B-lineage acute lymphoid leukemia (B-ALL) were C-KIT-negative (0/9). In the B-ALL patients, leukemic cells trom seven patients had one or more myeloid antigen such as CD13, CD15 and CD33. In contrast to C-KIT expression, leukemic cells from only one patient with acute monocytic leukemia were TIE-positive. Similarly, leukemic cells from only two patients (one, B-ALL with t(4:11)(q21:q23) and one, essential thrombocythemia in myeloblastic transformation (ET-MBT)) were HTK-positive. These results suggest that among the three receptor tyrosine kinases, C-KIT is the most useful marker for identifying AML.

元の言語English
ページ(範囲)827-830
ページ数4
ジャーナルLeukemia Research
22
発行部数9
DOI
出版物ステータスPublished - 1998 9 1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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