TY - JOUR
T1 - Analysis of comorbid factors that increase the COPD assessment test scores
AU - Miyazaki, Masaki
AU - Nakamura, Hidetoshi
AU - Chubachi, Shotaro
AU - Sasaki, Mamoru
AU - Haraguchi, Mizuha
AU - Yoshida, Shuichi
AU - Tsuduki, Keishi
AU - Shirahata, Toru
AU - Takahashi, Saeko
AU - Minematsu, Naoto
AU - Koh, Hidefumi
AU - Nakamura, Morio
AU - Sakamaki, Fumio
AU - Terashima, Takeshi
AU - Sayama, Koichi
AU - Jones, Paul W.
AU - Asano, Koichiro
AU - Betsuyaku, Tomoko
AU - Inoue, Takashi
AU - Miyao, Naoki
AU - Nishio, Kazumi
AU - Tateno, Hiroki
AU - Oyamada, Yoshitaka
AU - Matsuzaki, Tatsu
AU - Umeda, Akira
N1 - Funding Information:
TB discloses having received honoraria/paid expert testimony and her university having received research grants from GlaxoSmithKline. PWJ discloses that his university has received honoraria and research grants from GlaxoSmithKline. The other authors declare that they have no competing interests.
PY - 2014/2/6
Y1 - 2014/2/6
N2 - Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT scores.Methods: An observational study at Keio University and affiliated hospitals enrolled 336 COPD patients and 67 non-COPD subjects. Health status was assessed by the CAT, the St. Georges Respiratory Questionnaire (SGRQ), and all components of the Medical Outcomes Study Short-Form 36-Item (SF-36) version 2, which is a generic measure of health. Comorbidities were identified based on patients' reports, physicians' records, and questionnaires, including the Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (GERD) and the Hospital Anxiety and Depression Scale. Dual X-ray absorptiometry measurements of bone mineral density were performed.Results: The CAT showed moderate-good correlations with the SGRQ and all components of the SF-36. The presence of GERD, depression, arrhythmia, and anxiety was significantly associated with a high CAT score in the COPD patients.Conclusions: Symptomatic COPD patients have a high prevalence of comorbidities. A high CAT score should alert the clinician to a higher likelihood of certain comorbidities such as GERD and depression, because these diseases may co-exist unrecognized. Trial registration: Clinical trial registered with UMIN (UMIN000003470).
AB - Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT scores.Methods: An observational study at Keio University and affiliated hospitals enrolled 336 COPD patients and 67 non-COPD subjects. Health status was assessed by the CAT, the St. Georges Respiratory Questionnaire (SGRQ), and all components of the Medical Outcomes Study Short-Form 36-Item (SF-36) version 2, which is a generic measure of health. Comorbidities were identified based on patients' reports, physicians' records, and questionnaires, including the Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (GERD) and the Hospital Anxiety and Depression Scale. Dual X-ray absorptiometry measurements of bone mineral density were performed.Results: The CAT showed moderate-good correlations with the SGRQ and all components of the SF-36. The presence of GERD, depression, arrhythmia, and anxiety was significantly associated with a high CAT score in the COPD patients.Conclusions: Symptomatic COPD patients have a high prevalence of comorbidities. A high CAT score should alert the clinician to a higher likelihood of certain comorbidities such as GERD and depression, because these diseases may co-exist unrecognized. Trial registration: Clinical trial registered with UMIN (UMIN000003470).
KW - Chronic obstructive pulmonary disease
KW - Comorbidity
KW - Depression
KW - Gastro-esophageal reflux
KW - Health status
KW - Osteoporosis
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U2 - 10.1186/1465-9921-15-13
DO - 10.1186/1465-9921-15-13
M3 - Article
C2 - 24502760
AN - SCOPUS:84893198662
VL - 15
JO - Respiratory Research
JF - Respiratory Research
SN - 1465-9921
IS - 1
M1 - 13
ER -