Analysis of elasticity and deformability of erythrocytes using micro-channel flow system and atomic force microscope

Haruyuki Minamitani, Kosuke Tsukada, Tomoni Kawamura, Eiichi Sekizuka, Chikara Oshio

研究成果: Conference contribution

4 被引用数 (Scopus)

抄録

Mechanical properties of erythrocytes under diabetic and some other physico-chemical conditions were measured by using transparent micro-channel flow system for the analysis of erythrocyte deformability and also by using atomic force microscope (AFM) for the analysis of microscopic elasticity of the erythrocyte cell membrane respectively. Deformability of diabetic erythrocytes was significantly lower than that of healthy controls, especially at higher shear rate. The spring constant and the Young's modulus of diabetic erythrocytes were much higher than those of healthy controls. These erythrocytes were obviously stiffened to be hard to deform themselves in the capillary flow passage that may follow to the growth of microangiopathy.

本文言語English
ホスト出版物のタイトル1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
編集者Andre Dittmar, David Beebe
出版社Institute of Electrical and Electronics Engineers Inc.
ページ68-71
ページ数4
ISBN(電子版)0780366034, 9780780366039
DOI
出版ステータスPublished - 2000
イベント1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
継続期間: 2000 10 122000 10 14

出版物シリーズ

名前1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Other

Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
国/地域France
CityLyon
Period00/10/1200/10/14

ASJC Scopus subject areas

  • 工学(全般)

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