Anemia in female patients with myasthenia gravis

Koji Sekiguchi, Kei Ishizuchi, Tsubasa Takizawa, Haruhiko Motegi, Munenori Oyama, Jin Nakahara, Shigeaki Suzuki

研究成果: Article査読

抄録

Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder, and is more common in women than in men. Anemia is also more common in women. The purpose of this study was to investigate factors associated with anemia and the negative impact of anemia in female MG patients. We investigated factors related to MG and anemia in 215 female patients with MG, who were attending the MG clinic of Keio Hospital between January and December 2021. We statistically evaluated clinical factors related to anemia in patients with and without anemia. Eighty-five patients (40%) had anemia in the past, and 130 patients did not have anemia in the past. There were no significant differences in age at study, age at MG onset, body mass index, or frequency of autoantibodies between the anemia and non-anemia groups. MG severity evaluated by the MG Foundation of America classification was greater in the anemia group than in the non-anemia group. History of anemia was associated with immunosuppressive treatment, such as prednisolone and calcineurin inhibitor treatment. There was a correlation between hemoglobin levels and the MG-quality of life score. Long term immunosuppressive therapy can cause anemia in female MG patients. Anemia may negatively affect the quality of life of female MG patients.

本文言語English
論文番号e0273720
ジャーナルPloS one
17
9 September
DOI
出版ステータスPublished - 2022 9月

ASJC Scopus subject areas

  • 一般

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