Angioscope visualization in blood vessel using Ho:YAG laser-induced vapor bubble

E. Yamashita, Y. Oka, K. Kaneko, E. Suga, T. Arai

研究成果: Conference article査読

1 被引用数 (Scopus)


We proposed new method of blood removal using Ho:YAG laser(λ=2. 1μm)-induced water-vapor bubble to prevent distal tissue ischemia during angioscopic imaging. We successfully demonstrated capability of this blood removal method using blood-filled pocine coronary artery ex vivo. We used laser irradiation conditions of 200mJ in pulse energy and 2Hz in repetition rate. Ho:YAG laser for blood removal and flash lamp lighting for endoscopic illumination were irradiated in the porcine coronary artery through individual fiber optics. Timing of the flash lamp lightning of 2 μ s in duration was arranged to illuminate the maximum blood removal space, i.e. the laser induced water-vapor bubble. We successfully obtained intra-lumen view via a thin angioscope using the laser blood removal without using saline injection. We studied to determine the optimum laser-induced bubble formation which indicated the minimum invasion against the blood vessel. The time resolved photography In vitro, transient pressure measurement in vitro, and acute historogical study on irradiated vessel wall in vivo were employed for this determination.

ジャーナルProgress in Biomedical Optics and Imaging - Proceedings of SPIE
出版ステータスPublished - 2005 8 16
イベントPhotonic Therapeutics and Diagnostics - San Jose, CA, United States
継続期間: 2005 1 222005 1 25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング


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