We proposed new method of blood removal using Ho:YAG laser(λ=2. 1μm)-induced water-vapor bubble to prevent distal tissue ischemia during angioscopic imaging. We successfully demonstrated capability of this blood removal method using blood-filled pocine coronary artery ex vivo. We used laser irradiation conditions of 200mJ in pulse energy and 2Hz in repetition rate. Ho:YAG laser for blood removal and flash lamp lighting for endoscopic illumination were irradiated in the porcine coronary artery through individual fiber optics. Timing of the flash lamp lightning of 2 μ s in duration was arranged to illuminate the maximum blood removal space, i.e. the laser induced water-vapor bubble. We successfully obtained intra-lumen view via a thin angioscope using the laser blood removal without using saline injection. We studied to determine the optimum laser-induced bubble formation which indicated the minimum invasion against the blood vessel. The time resolved photography In vitro, transient pressure measurement in vitro, and acute historogical study on irradiated vessel wall in vivo were employed for this determination.
|ジャーナル||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|出版ステータス||Published - 2005 8 16|
|イベント||Photonic Therapeutics and Diagnostics - San Jose, CA, United States|
継続期間: 2005 1 22 → 2005 1 25
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