Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Sho Ichi Yamagishi, Masayoshi Takeuchi, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Hiroyoshi Inoue

研究成果: Article査読

74 被引用数 (Scopus)

抄録

Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

本文言語English
ページ(範囲)4265-4270
ページ数6
ジャーナルFEBS Letters
579
20
DOI
出版ステータスPublished - 2005 8 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル