Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Sho Ichi Yamagishi; Masayoshi Takeuchi; Takanori Matsui; Kazuo Nakamura; Tsutomu Imaizumi; Hiroyoshi Inoue

doi:10.1016/j.febslet.2005.06.058

Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Sho Ichi Yamagishi, Masayoshi Takeuchi, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Hiroyoshi Inoue

研究成果: Article › 査読

76 被引用数 (Scopus)

抄録

Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

本文言語	English
ページ（範囲）	4265-4270
ページ数	6
ジャーナル	FEBS Letters
巻	579
号	20
DOI	https://doi.org/10.1016/j.febslet.2005.06.058
出版ステータス	Published - 2005 8月 15
外部発表	はい

ASJC Scopus subject areas

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/j.febslet.2005.06.058

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引用スタイル

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title = "Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression",

abstract = "Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.",

keywords = "Advanced glycation end products, Angiotensin II, Diabetic retinopathy, Oxidative stress, Pericyte loss, Receptor for AGEs",

author = "Yamagishi, {Sho Ichi} and Masayoshi Takeuchi and Takanori Matsui and Kazuo Nakamura and Tsutomu Imaizumi and Hiroyoshi Inoue",

note = "Funding Information: This work was supported in part by Grants of Collaboration with Venture Companies Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan (S. Yamagishi).",

year = "2005",

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doi = "10.1016/j.febslet.2005.06.058",

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T1 - Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

AU - Yamagishi, Sho Ichi

AU - Takeuchi, Masayoshi

AU - Matsui, Takanori

AU - Nakamura, Kazuo

AU - Imaizumi, Tsutomu

AU - Inoue, Hiroyoshi

N1 - Funding Information: This work was supported in part by Grants of Collaboration with Venture Companies Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan (S. Yamagishi).

PY - 2005/8/15

Y1 - 2005/8/15

N2 - Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

AB - Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

KW - Advanced glycation end products

KW - Angiotensin II

KW - Diabetic retinopathy

KW - Oxidative stress

KW - Pericyte loss

KW - Receptor for AGEs

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Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

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ASJC Scopus subject areas

UN SDG

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