Angiotensin II receptor subtype in human adrenal glands

A. Tanabe, M. Naruse, K. Naruse, T. Yoshimoto, M. Tanaka, N. Mishina, T. Imaki, K. Sugaya, H. Miyazaki, H. Demura

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

Although adrenal gland is one of the major target organs of angiotensin II (Ang II), the pathophysiological significance of the its receptor subtype has not been elucidated. We demonstrated by reverse transcription-polymerase chain reaction with Southern blot analysis mRNA expression of both AT1 and AT2 in human adrenal tissues of normal adrenocortical tissues, aldosterone-producing adenoma, Cushing's syndrome, and pheochromocytoma. Ang II-induced aldosterone secretion in vitro was suppressed only by 50% in the presence of selective AT1 antagonist CV-11974, while AT2 agonist CGP-42112 increased aldosterone secretion by 55% over the control. Ang II or CGP-42112 did not affect cortisol secretion. In addition, Ang II could stimulate aldosterone secretion in AT1a knockout mice both in the presence and absence of CV-11974. These results suggest that non-AT1 receptor subtype(s) including AT2, as well as AT1, is involved in the stimulation of aldosterone secretion from human adrenals.

本文言語English
ページ(範囲)1042-1048
ページ数7
ジャーナルNippon rinsho. Japanese journal of clinical medicine
57
5
出版ステータスPublished - 1999 5

ASJC Scopus subject areas

  • Medicine(all)

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