Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis

T. Hibi, S. Aiso, T. Yoshida, M. Watanabe, H. Asakura, S. Tsuru, M. Tsuchiya

研究成果: Article査読

31 被引用数 (Scopus)

抄録

The presence of anti-colon antibody in the sera from patients with ulcerative colitis was demonstrated by antibody-dependent cell-mediated cytotoxicity (ADCC) assay. In addition, the high prevalence of lymphocytophilic antibody in the sera from patients with ulcerative colitis was obtained by fluorescence activated cell sorter (FACS) analysis. This lymphocytophilic antibody was absorbed by rat colon epithelial cells. Moreover the lymphocytes from ulcerative colitis showed lower binding capacity to this antibody, but acquired higher binding capacity after 20 hr incubation at 37°C in vitro. These data suggest that ADCC may have some role in the pathogenesis of ulcerative colitis.

本文言語English
ページ(範囲)75-80
ページ数6
ジャーナルClinical and Experimental Immunology
49
1
出版ステータスPublished - 1982

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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