Anti-selective direct catalytic asymmetric aldol reaction of thiolactams

Devarajulu Sureshkumar, Yuji Kawato, Mitsutaka Iwata, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

21 被引用数 (Scopus)

抄録

An anti-selective direct catalytic asymmetric aldol reaction of thiolactam is described. A soft Lewis acid/hard Brønsted base cooperative catalyst comprised of mesitylcopper/(R,R)-Ph-BPE exhibited high catalytic performance to produce an anti-aldol product with high stereoselectivity. The highly chemoselective nature of the present catalysis allows for the use of enolizable aldehydes as aldol acceptors. The diverse transformations of the thiolactam moiety highlight the synthetic utility of the present anti-aldol protocol.

本文言語English
ページ(範囲)3108-3111
ページ数4
ジャーナルOrganic Letters
14
12
DOI
出版ステータスPublished - 2012 6 15
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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