抄録
An anti-selective direct catalytic asymmetric aldol reaction of thiolactam is described. A soft Lewis acid/hard Brønsted base cooperative catalyst comprised of mesitylcopper/(R,R)-Ph-BPE exhibited high catalytic performance to produce an anti-aldol product with high stereoselectivity. The highly chemoselective nature of the present catalysis allows for the use of enolizable aldehydes as aldol acceptors. The diverse transformations of the thiolactam moiety highlight the synthetic utility of the present anti-aldol protocol.
本文言語 | English |
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ページ(範囲) | 3108-3111 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 14 |
号 | 12 |
DOI | |
出版ステータス | Published - 2012 6月 15 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学