Anti-SRP myopathy: Different entity from myositis

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Anti-signal recognition particle (SRP) antibody, detected in 5-8% of patients with clinical diagnosis of myositis, had been associated with severe and refractory myositis. However, it has been accepted that anti-SRP myopathy should be separated from myositis based on histological features of necrotizing myopathy. We reviewed clinical features of 27 patients with anti-SRP myopathy, and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (18.5%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared to the other 22 patients with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.

本文言語English
ページ(範囲)1148-1150
ページ数3
ジャーナルClinical Neurology
52
11
DOI
出版ステータスPublished - 2012 12 1

ASJC Scopus subject areas

  • 臨床神経学

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