TY - JOUR
T1 - Anti-thrombogenicity by layer-by-layer
T2 - 14th International Conference on Organized Molecular Films, ICOMF 2013
AU - Shiratori, Seimei
AU - Matsuda, Tomomi
PY - 2013
Y1 - 2013
N2 - Anti-thrombogenic films with high durability were fabricated in a wet process. Anti-thrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid)(PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming crosslinks via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. Anti-thrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 minutes, whereas with uncoated mesh blood flow stopped within 6 minutes because of blood vessel blockage by thrombus formation.
AB - Anti-thrombogenic films with high durability were fabricated in a wet process. Anti-thrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid)(PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming crosslinks via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. Anti-thrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 minutes, whereas with uncoated mesh blood flow stopped within 6 minutes because of blood vessel blockage by thrombus formation.
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U2 - 10.1051/matecconf/20130402003
DO - 10.1051/matecconf/20130402003
M3 - Conference article
AN - SCOPUS:84903577413
VL - 4
JO - MATEC Web of Conferences
JF - MATEC Web of Conferences
SN - 2261-236X
M1 - 02003
Y2 - 10 July 2013 through 13 July 2013
ER -