Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines

Takeshi Nara, Kyoichi Iizumi, Hiroshi Ohmae, Orlando Sy, Soichi Tsubota, Yutaka Inaba, Akiko Tsubouchi, Masanobu Tanabe, Somei Kojima, Takashi Aoki

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and that the epitopes responsible were localized predominantly within the N-terminal half of PM. In addition, the IgG3 response to PM was associated with serum level of procollagen-III-peptide (P-III-P), an indicator of progression of liver fibrosis. These results imply that IgG3 against PM may not only provoke age-dependent resistance to S. japonicum infection but also enhance liver fibrosis. In contrast, levels of IgE to PM and to multiple PM fragments showed a negative correlation with P-III-P level. Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.

本文言語English
ページ(範囲)384-391
ページ数8
ジャーナルAmerican Journal of Tropical Medicine and Hygiene
76
2
DOI
出版ステータスPublished - 2007 2

ASJC Scopus subject areas

  • 寄生虫科
  • ウイルス学
  • 感染症

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