Antibody to the inositol trisphosphate receptor blocks thimerosalenhanced Ca2+-induced Ca2+ release and Ca2+ oscillations in hamster eggs

Shun ichi Miyazaki, Hideki Shirakawa, Ken Nakada, Yoshiko Honda, Michisuke Yuzaki, Shinji Nakade, Katsuhiko Mikoshiba

研究成果: Article査読

87 被引用数 (Scopus)

抄録

The sulfhydryl reagent thimerosal enhanced the sensitivity of hamster eggs to injected inositol 1,4,5-trisphosphate (InsP3) or Ca2+ to generate regenerative Ca2+ release from intracellular pools. A monoclonal antibody (mAb) to the InsP3 receptor blocked both the InsP3-induced Ca2+ release (IICR) and Ca2+-induced Ca2+ release (CICR). The mAb also blocked Ca2+ oscillations induced by thimerosal. The results indicate that thimerosal enhances IICR sensitized by cytosolic Ca2+, but not CICR from InsP3-insensitive pools, and causes repetitive Ca2+ releases from InsP3-sensitive pools.

本文言語English
ページ(範囲)180-184
ページ数5
ジャーナルFEBS Letters
309
2
DOI
出版ステータスPublished - 1992 9月 7
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Antibody to the inositol trisphosphate receptor blocks thimerosalenhanced Ca2+-induced Ca2+ release and Ca2+ oscillations in hamster eggs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル