Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Toru Yagura; Tomoko Motomiya; Michiho Ito; Gisho Honda; Akira Iida; Fumiyuki Kiuchi; Harukuni Tokuda; Hoyoku Nishino

doi:10.1007/s11418-007-0223-y

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Toru Yagura, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino

研究成果: Article › 査読

35 被引用数 (Scopus)

抄録

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

本文言語	English
ページ（範囲）	174-178
ページ数	5
ジャーナル	Journal of Natural Medicines
巻	62
号	2
DOI	https://doi.org/10.1007/s11418-007-0223-y
出版ステータス	Published - 2008 4
外部発表	はい

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

文献へのアクセス

10.1007/s11418-007-0223-y

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引用スタイル

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abstract = "An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.",

keywords = "Anticarcinogenic activity, Helichrysum maracandicum, Isosalipurposide, Naringenin chalcone, Two-stage carcinogenesis",

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AU - Yagura, Toru

AU - Motomiya, Tomoko

AU - Ito, Michiho

AU - Honda, Gisho

AU - Iida, Akira

AU - Kiuchi, Fumiyuki

AU - Tokuda, Harukuni

AU - Nishino, Hoyoku

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N2 - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

AB - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

KW - Anticarcinogenic activity

KW - Helichrysum maracandicum

KW - Isosalipurposide

KW - Naringenin chalcone

KW - Two-stage carcinogenesis

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