Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Nahoko Uchiyama, Zakayi Kabututu, Bruno K. Kubata, Fumiyuki Kiuchi, Michiho Ito, Junko Nakajima-Shimada, Takashi Aoki, Kei Ohkubo, Shunichi Fukuzumi, Samuel K. Martin, Gisho Honda, Yoshihiro Urade

研究成果: Article査読

37 被引用数 (Scopus)

抄録

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

本文言語English
ページ(範囲)5123-5126
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
49
12
DOI
出版ステータスPublished - 2005 12月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

フィンガープリント

「Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル