Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats

Hiroshi Itoh, Kazuwa Nakao, Takayuki Yamada, Gotaro Shirakami, Kenji Kangawa, Naoto Minamimo, Hisayuki Matsuo, Hiroo Imura

研究成果: Article査読

74 被引用数 (Scopus)

抄録

The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.

本文言語English
ページ(範囲)193-196
ページ数4
ジャーナルEuropean journal of pharmacology
150
1-2
DOI
出版ステータスPublished - 1988 5 20
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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