TY - JOUR
T1 - Antidipsogenic action of a novel peptide, 'brain natriuretic peptide', in rats
AU - Itoh, Hiroshi
AU - Nakao, Kazuwa
AU - Yamada, Takayuki
AU - Shirakami, Gotaro
AU - Kangawa, Kenji
AU - Minamimo, Naoto
AU - Matsuo, Hisayuki
AU - Imura, Hiroo
N1 - Funding Information:
The authors wish to thank Ms. H. Tabata and Ms. A. Furu for secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare'Disorders of Adrenal Hormone' Research Committee, Japan, 1987, Life Science Research Project of Institute of Physical and Chemical Research (RIKEN), Japan Tobacco Inc. and Yamanouchi Foundation for Research on Metabolic Disorders, by research grants for cardiovascular diseases ((60A-3) and (62A'-1)) from the Japanese Ministry of Health and Welfare.
PY - 1988/5/20
Y1 - 1988/5/20
N2 - The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.
AB - The effect of intracerebroventricular (i.c.v.) administration of brain natriuretic peptide (BNP) on water drinking was studied in rats. The i.c.v. injection of BNP at a dose of 1.5 nmol elicited no apparent change in spontaneous water intake in rats but significantly attenuated the water intake induced by the i.c.v. administration of 0.1 nmol of angiotensin II. The antidipsogenic action of BNP was comparable to that of atrial natriuretic polypeptide (ANP). These findings suggest that BNP could play a role in the regulation of water intake in the central nervous system, either alone or in concert with brain ANP.
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U2 - 10.1016/0014-2999(88)90769-8
DO - 10.1016/0014-2999(88)90769-8
M3 - Article
C2 - 2969822
AN - SCOPUS:0023911618
SN - 0014-2999
VL - 150
SP - 193
EP - 196
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -