Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: A near-infrared spectroscopy (NIRS) study

Takeo Tsujii, Eriko Yamamoto, Takayuki Ohira, Takao Takahashi, Shigeru Watanabe

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Histamine H1 receptor antagonists (antihistamines) are widely used for the treatment of allergic disorders in young children. This study examined the effects of antihistamine on prefrontal cortex activity in preschool children using near-infrared spectroscopy (NIRS), an emerging brain-imaging method suitable for psychological experiments, especially in young children. We examined the changes of oxygenated hemoglobin concentration in the prefrontal cortex while children performed a spatial working memory task, 3h after taking a first-generation antihistamine (ketotifen), second-generation antihistamine (epinastine), or placebo. Fifteen healthy preschool children (mean age, 5.5 years) participated. Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex in the working memory task, compared with epinastine and placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. This paper demonstrates for the first time differential sedation effects of first- and second-generation antihistamines on brain hemodynamic response in young children. Also discussed is the utility of the NIRS technique in neuropsychopharmacological studies of children.

本文言語English
ページ(範囲)80-85
ページ数6
ジャーナルNeuroscience Research
67
1
DOI
出版ステータスPublished - 2010 5月

ASJC Scopus subject areas

  • 神経科学(全般)

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