Antihypertensive action of melatonin in the spontaneously hypertensive rat

Koichiro Kawashima, Yuko Miwa, Kazuko Fujimoto, Hisayo Oohata, Hiroshi Nishino, Hiroyuki Koike

研究成果: Article査読

90 被引用数 (Scopus)

抄録

The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.

本文言語English
ページ(範囲)1121-1131
ページ数11
ジャーナルClinical and Experimental Hypertension
A9
7
DOI
出版ステータスPublished - 1987

ASJC Scopus subject areas

  • 内科学
  • 生理学

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