Antimycobacterial flavonoids from the leaf extract of Galenia africana

Sannah P.N. Mativandlela, Tshilidzi Muthivhi, Haruhisa Kikuchi, Yoshiteru Oshima, Chris Hamilton, Ahmed A. Hussein, Martha L. Van Der Walt, Peter J. Houghton, Namrita Lall

研究成果: Article査読

27 被引用数 (Scopus)

抄録

The bioassay-guided fractionation of the EtOH extract of the leaves of Galenia africana led to the isolation of three known flavonoids, (2S)-5,7,2′-trihydroxyflavanone (1), (E)-3,2′,4′- trihydroxychalcone (2), and (E)-2′,4′-dihydroxychalcone (3), and the new (E)-3,2′,4′-trihydroxy-3′-methoxychalcone (4). Compounds 1 and 3 exhibited moderate antituberculosis activity. During synergistic studies, a combination of compound 4 and an existing antituberculosis drug, isoniazid, reduced their original MICs 4-fold, resulting in a fractional inhibitory concentration of 0.50. The most pronounced effect was demonstrated by compound 1 and isoniazid reducing their MICs 16-fold and resulting in an FIC of 0.12. Both EtOH extract and isolated compounds failed to exhibit any NADPH oxidase activity at 800.0 μM concentrations, indicating that mycothiol disulfide reductase is not the target for their antituberculosis activity.

本文言語English
ページ(範囲)2169-2171
ページ数3
ジャーナルJournal of Natural Products
72
12
DOI
出版ステータスPublished - 2009 12 28
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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