Antithrombogenicity of fluorinated diamond-like carbon films

T. Saito, T. Hasebe, S. Yohena, Y. Matsuoka, A. Kamijo, K. Takahashi, T. Suzuki

研究成果: Article査読

107 被引用数 (Scopus)

抄録

Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

本文言語English
ページ(範囲)1116-1119
ページ数4
ジャーナルDiamond and Related Materials
14
3-7
DOI
出版ステータスPublished - 2005 3

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 化学 (全般)
  • 機械工学
  • 材料化学
  • 電子工学および電気工学

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