TY - JOUR
T1 - Antithrombogenicity of fluorinated diamond-like carbon films
AU - Saito, T.
AU - Hasebe, T.
AU - Yohena, S.
AU - Matsuoka, Y.
AU - Kamijo, A.
AU - Takahashi, K.
AU - Suzuki, T.
PY - 2005/3
Y1 - 2005/3
N2 - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.
AB - Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H 2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.
KW - Antithrombogenicity
KW - Fluorinated diamond-like carbon
KW - Hydrophobicity
KW - Platelet adhesion
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U2 - 10.1016/j.diamond.2004.09.017
DO - 10.1016/j.diamond.2004.09.017
M3 - Article
AN - SCOPUS:18444411390
SN - 0925-9635
VL - 14
SP - 1116
EP - 1119
JO - Diamond and Related Materials
JF - Diamond and Related Materials
IS - 3-7
ER -