Antitumor Activity of Erbstatin, A Tyrosine Protein Kinase Inhibitor

Masaya Imoto, Keiko Komuro, Tsutomu Sawa, Tomio Takeuchi, Hamao Umezawa, Kazuo Umezawa

研究成果: Article査読

51 被引用数 (Scopus)

抄録

A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.

本文言語English
ページ(範囲)329-332
ページ数4
ジャーナルJapanese Journal of Cancer Research
78
4
出版ステータスPublished - 1987 1月 1
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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