Antitumor effect of piericidin B1 N-oxide

Hiroshi Nishioka, Tsutomu Sawa, Tomio Takeuchi, Masaya Imoto, Tomomi Imaoka, Kazuo Umezawa

研究成果: Article

16 引用 (Scopus)

抜粋

Piericidin B1 N-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI) turnover. Piericidin B1 N-oxide specifically inhibited orthophosphate labeling of PI induced by epidermal growth factor (EGF) without affecting the formation of phosphatidic acid (PA). Like piericidins A1 and B1, piericidin B1 N-oxide inhibited ATP synthesis in A431 cells; however, the effect of piericidin B1 N-oxide on PI synthesis was stronger than that of piericidins A1 and B1. At the concentration inhibiting PI synthesis, piericidin B1 N-oxide showed no inhibitory effect on DNA, RNA, or protein synthesis. We also demonstrated that piericidin B1 N-oxide reversibly inhibited the growth of A431 cells in situ and suppressed the growth of Ehrlich carcinoma in vivo when administered to mice by intraperitoneal (ip) injection.

元の言語English
ページ(範囲)447-452
ページ数6
ジャーナルThe Journal of Antibiotics
47
発行部数4
DOI
出版物ステータスPublished - 1994 1 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

フィンガープリント Antitumor effect of piericidin B<sub>1</sub> N-oxide' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Nishioka, H., Sawa, T., Takeuchi, T., Imoto, M., Imaoka, T., & Umezawa, K. (1994). Antitumor effect of piericidin B1 N-oxide. The Journal of Antibiotics, 47(4), 447-452. https://doi.org/10.7164/antibiotics.47.447