Antitumor effect of piericidin B1 N-oxide

Hiroshi Nishioka, Tsutomu Sawa, Tomio Takeuchi, Masaya Imoto, Tomomi Imaoka, Kazuo Umezawa

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Piericidin B1 N-oxide was isolated from a culture broth of Streptomyces sp. as a novel inhibitor of phosphatidylinositol (PI) turnover. Piericidin B1 N-oxide specifically inhibited orthophosphate labeling of PI induced by epidermal growth factor (EGF) without affecting the formation of phosphatidic acid (PA). Like piericidins A1 and B1, piericidin B1 N-oxide inhibited ATP synthesis in A431 cells; however, the effect of piericidin B1 N-oxide on PI synthesis was stronger than that of piericidins A1 and B1. At the concentration inhibiting PI synthesis, piericidin B1 N-oxide showed no inhibitory effect on DNA, RNA, or protein synthesis. We also demonstrated that piericidin B1 N-oxide reversibly inhibited the growth of A431 cells in situ and suppressed the growth of Ehrlich carcinoma in vivo when administered to mice by intraperitoneal (ip) injection.

本文言語English
ページ(範囲)447-452
ページ数6
ジャーナルThe Journal of Antibiotics
47
4
DOI
出版ステータスPublished - 1994 1 1

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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