Aplastic anemia complicated with secondary hemochromatosis after allogenic bone marrow transplantation

T. Oguchi, K. Kitano, H. Kobayashi, H. Saito, S. Okamoto, K. Kiyosawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We report a case of aplastic anemia complicated with secondary hemochromatosis after allogenic bone marrow transplantation (BMT). A 29-year-old man was diagnosed as having aplastic anemia at the age of 8. At the age of 28, BMT was performed from his HLA-identical sister. Total volume of blood transfusion before BMT was about 28,000 ml, and in three months after BMT was 8,000 ml. The transplantation was successful, but one month after BMT, dry eyes, skin pigmentation and hepatomegaly appeared. Serum bile duct enzymes and ferritin also increased remarkably. Moreover after thirteen months, glucose tolerance impaired seriously. Abdominal computed tomography (CT) revealed atrophic pancreas and an increased CT density in the liver and the tail of the pancreas. A large amount of iron deposition were also found in liver and stomach biopsy specimens. We concluded that diabetes mellitus was due to secondary hemochtomatosis in the present case. There is a possibility that tissue damage due to iron deposits may have been accelerated through BMT in this patient with a history of many blood transfusions.

本文言語English
ページ(範囲)1188-1192
ページ数5
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
36
10
出版ステータスPublished - 1995 10
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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