Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: Chemistry and biology

Kiyoyuki Yamada, Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga

研究成果: Review article査読

39 被引用数 (Scopus)

抄録

Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.

本文言語English
ページ(範囲)27-43
ページ数17
ジャーナルNatural Product Reports
26
1
DOI
出版ステータスPublished - 2009 1 6

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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