Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity

Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga, Yoshifumi Imamura, Kohji Yoshikawa, Takeshi Ishigaki, Akira Sakakura, Tsuyoshi Mutou, Kiyoyuki Yamada

研究成果: Article

12 引用 (Scopus)

抄録

Five cytotoxic macrolides, aplyronines D-H (4-8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures were determined by spectroscopic analysis (NMR and MS). The cytotoxicity of these new compounds was evaluated in comparison with that of aplyronines A-C (1-3), suggesting the importance of the 7-O-seryl ester group for mediating the potent cytotoxicity of aplyronines.

元の言語English
ページ(範囲)982-987
ページ数6
ジャーナルTetrahedron
68
発行部数4
DOI
出版物ステータスPublished - 2012 1 28

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Aplysia
Cytotoxicity
Oceans and Seas
Spectroscopic analysis
Macrolides
Esters
Nuclear magnetic resonance
aplyronine A
aplyronine C

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

これを引用

Ojika, M., Kigoshi, H., Suenaga, K., Imamura, Y., Yoshikawa, K., Ishigaki, T., ... Yamada, K. (2012). Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity. Tetrahedron, 68(4), 982-987. https://doi.org/10.1016/j.tet.2011.11.095

Aplyronines D-H from the sea hare Aplysia kurodai : Isolation, structures, and cytotoxicity. / Ojika, Makoto; Kigoshi, Hideo; Suenaga, Kiyotake; Imamura, Yoshifumi; Yoshikawa, Kohji; Ishigaki, Takeshi; Sakakura, Akira; Mutou, Tsuyoshi; Yamada, Kiyoyuki.

:: Tetrahedron, 巻 68, 番号 4, 28.01.2012, p. 982-987.

研究成果: Article

Ojika, M, Kigoshi, H, Suenaga, K, Imamura, Y, Yoshikawa, K, Ishigaki, T, Sakakura, A, Mutou, T & Yamada, K 2012, 'Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity', Tetrahedron, 巻. 68, 番号 4, pp. 982-987. https://doi.org/10.1016/j.tet.2011.11.095
Ojika, Makoto ; Kigoshi, Hideo ; Suenaga, Kiyotake ; Imamura, Yoshifumi ; Yoshikawa, Kohji ; Ishigaki, Takeshi ; Sakakura, Akira ; Mutou, Tsuyoshi ; Yamada, Kiyoyuki. / Aplyronines D-H from the sea hare Aplysia kurodai : Isolation, structures, and cytotoxicity. :: Tetrahedron. 2012 ; 巻 68, 番号 4. pp. 982-987.
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AU - Suenaga, Kiyotake

AU - Imamura, Yoshifumi

AU - Yoshikawa, Kohji

AU - Ishigaki, Takeshi

AU - Sakakura, Akira

AU - Mutou, Tsuyoshi

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