Apolipoprotein B-48: A unique marker of chylomicron metabolism

Katsuyuki Nakajima, Takeaki Nagamine, Masaki Q. Fujita, Masumi Ai, Akira Tanaka, Ernst Schaefer

研究成果: Chapter

26 被引用数 (Scopus)

抄録

Apolipoprotein B-48 (apoB-48) is known to be the only specific marker of intestinal chylomicron particles. The amino acid sequence of apoB-48 represents 48% of the initial sequence of apoB-100. ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver. Therefore, apoB-48 is a most appropriate biomarker for cardiovascular and nutritional investigation of postprandial chylomicron metabolism. In this review article, we discussed the difference between the recent findings and Zilversmit's proposal of postprandial hyperlipidemia reported over 30 years ago. The characteristics and role of apoB-48 as an apolipoprotein in chylomicrons, especially as a marker of chylomicron remnant lipoproteins, are described. The need for appropriate analytical methods to measure apoB-48 is also discussed.

本文言語English
ホスト出版物のタイトルAdvances in Clinical Chemistry
出版社Academic Press Inc.
ページ117-177
ページ数61
DOI
出版ステータスPublished - 2014

出版物シリーズ

名前Advances in Clinical Chemistry
64
ISSN(印刷版)0065-2423

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

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