Apolipoprotein E ξ4 allele and pupillary response to tropicamide

Susumu Higuchi, Sachio Matsushita, Yoshio Hasegawa, Taro Muramatsu, Hiroyuki Arai, Motoi Hayashida

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Objective: This study was designed to investigate in cognitively normal subjects the possible association between hypersensitive pupil dilation responses to the cholinergic antagonist tropicamide and the presence of the apolipoprotein E ξ4 (APOE4) allele, a well-defined genetic risk factor for Alzheimer's disease. Method: The authors measured tropicamide-induced changes in pupil area in 44 cognitively normal Japanese subjects with and without the APOE4 allele. Results: The subjects with the APOE4 allele had significantly greater increases in pupil area than the others. The significant correlation of changes in pupil area with age for the subjects with the APOE4 allele was lacking for those without this allele. Conclusions: The results suggest that a hypersensitive pupil dilation response to tropicamide is already present in cognitively normal individuals with the APOE4 allele. This association also suggests the potential involvement of APOE4 in the mechanism of pupil dilation.

本文言語English
ページ(範囲)694-696
ページ数3
ジャーナルAmerican Journal of Psychiatry
154
5
DOI
出版ステータスPublished - 1997 5
外部発表はい

ASJC Scopus subject areas

  • 精神医学および精神衛生

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