TY - JOUR
T1 - Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex
AU - Huang, Ying
AU - Ohno, Osamu
AU - Suenaga, Kiyotake
AU - Miyamoto, Kenji
N1 - Publisher Copyright:
© 2017 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2017
Y1 - 2017
N2 - Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.
AB - Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.
KW - Antiproliferative activity
KW - Apoptosis
KW - Caspase-3 activation
KW - Paeonia suffruticosa Andr.
KW - Paeoniflorigenone
UR - http://www.scopus.com/inward/record.url?scp=85019584135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019584135&partnerID=8YFLogxK
U2 - 10.1080/09168451.2017.1300517
DO - 10.1080/09168451.2017.1300517
M3 - Article
C2 - 28317437
AN - SCOPUS:85019584135
SN - 0916-8451
VL - 81
SP - 1106
EP - 1113
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 6
ER -
