Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex

Ying Huang, Osamu Ohno, Kiyotake Suenaga, Kenji Miyamoto

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.

本文言語English
ページ(範囲)1106-1113
ページ数8
ジャーナルBioscience, Biotechnology and Biochemistry
81
6
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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