Application of chemical cytochrome P450 model systems to studies on drug metabolism .VI: N, N-coupling reaction of N-methylaniline catalyzed by polypeptide-bound porphyrinatoiron(III) and cytochrome P450

Takuko Doi, Takashi Mori, Tadamko Mashino, Masaaki Hirobe

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Polypeptide-bound porphyrinatoiron(III) effectively catalyzed the N, N coupling reaction of N-methylaniline in the presence of NaBH4/O2/tetramethyl-ammonium hydroxide or cumenehydroperoxide, whereas the corresponding non-bound monomer porphyrinatoiron(III) had little catalytic activity. Rat liver microsomes also catalyzed the N, N-coupling which was inhibited by cytochrome P-450 specific inhibitors, SKF-525A and metyrapone. The polypeptide-bound porphinatoiron(III) appears to be an excellent cytochrome P450 model for drug metabolism studies.

本文言語English
ページ(範囲)737-743
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
191
2
DOI
出版ステータスPublished - 1993 3月 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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