TY - CHAP
T1 - Application of microRNA in the treatment and diagnosis of cervical cancer
AU - Banno, Kouji
AU - Iida, Miho
AU - Yanokura, Megumi
AU - Kisu, Iori
AU - Nakamura, Kanako
AU - Adachi, Masataka
AU - Iwata, Takashi
AU - Tanaka, Kyoko
AU - Aoki, Daisuke
PY - 2014/2/1
Y1 - 2014/2/1
N2 - MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.
AB - MicroRNAs (miRNAs) are small non-coding RNA molecules of 20-23 nucleotides that regulate gene expression by binding to complementary mRNA sequences. Aberrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells. Recent studies using miRNAs with different expression patterns between normal and cancer tissues have proposed use of miRNAs as biomarkers for cancer diagnosis and as treatment targets. In cervical cancer, miRNAs may be useful for onset detection, diagnosis and treatment. Here, we review the potential clinical applications of miRNAs for diagnosis and as a therapeutic strategy in cervical cancer.
UR - http://www.scopus.com/inward/record.url?scp=84930067010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930067010&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-05134-5_7
DO - 10.1007/978-3-319-05134-5_7
M3 - Chapter
AN - SCOPUS:84930067010
SN - 3319051334
SN - 9783319051338
SP - 129
EP - 137
BT - MicroRNA Targeted Cancer Therapy
PB - Springer International Publishing
ER -
