Aquaporins and disease: Lessons from mice to humans

Landon S. King, Masato Yasui

研究成果: Review article査読

68 被引用数 (Scopus)

抄録

Recent discovery of a family of water-specific membrane channel proteins, the aquaporins, has provided new insights into the molecular basis of membrane water permeability. Eleven mammalian aquaporins have been identified to date, with homolog present across the spectrum of life, including bacteria, yeast and plants. The distribution of the mammalian aquaporins predicts their participation in a range of pathophysiological events. Empirical evidence of a physiological role for aquaporins is emerging from studies in both mice and humans, and suggests that aquaporins are likely to play significant roles in human pathophysiology.

本文言語English
ページ(範囲)355-360
ページ数6
ジャーナルTrends in Endocrinology and Metabolism
13
8
DOI
出版ステータスPublished - 2002 10月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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