TY - JOUR
T1 - Aquaporins in health and disease
AU - King, Landon S.
AU - Yasui, Masato
AU - Agre, Peter
N1 - Funding Information:
This work was supported by the National Institutes of Health (L.K. and P.A.), the Cystic Fibrosis Foundation (L.K. and P.A.) and the Human Frontier Science Program (M.Y.).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.
AB - The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.
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U2 - 10.1016/s1357-4310(99)01636-6
DO - 10.1016/s1357-4310(99)01636-6
M3 - Review article
C2 - 10652478
AN - SCOPUS:0033969517
VL - 6
SP - 60
EP - 65
JO - Molecular Medicine
JF - Molecular Medicine
SN - 1076-1551
IS - 2
ER -