Aquaporins in health and disease

Landon S. King, Masato Yasui, Peter Agre

研究成果: Review article査読

124 被引用数 (Scopus)

抄録

The molecular basis of membrane water-permeability remained elusive until the recent discovery of the aquaporin water-channel proteins. The fundamental importance of these proteins is suggested by their conservation from bacteria through plants to mammals. Ten mammalian aquaporins have thus far been identified, each with a distinct distribution. In the kidney, lung, eye and brain, multiple water-channel homologs are expressed, providing a network for water transport in those locations. It is increasingly clear that alterations in aquaporin expression or function can be rate-limiting for water transport across certain membranes. Aquaporins are likely to prove central to the pathophysiology of a variety of clinical conditions from diabetes insipidus to various forms of edema and, ultimately, they could be a target for therapy in diseases of altered water homeostasis.

本文言語English
ページ(範囲)60-65
ページ数6
ジャーナルMolecular Medicine
6
2
DOI
出版ステータスPublished - 2000 2
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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