Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just 'witnesses of disease'?

Masayuki Amagai, A. R. Ahmed, Y. Kitajima, J. C. Bystryn, Y. Milner, R. Gniadecki, M. Hertl, C. Pincelli, M. Fridkis-Hareli, Y. Aoyama, M. Frušić-Zlotkin, E. Müller, M. David, D. Mimouni, D. Vind-Kezunovic, B. Michel, M. Mahoney