Are doctors aware of the PK-PD-based antimicrobial agent dosage and how to apply it? - Involving clinicians/practitioners

Junko Kizu, Tomoko Terajima, Kayoko Maezawa, Hironobu Akita, Seiji Hori

研究成果: Article

抄録

Performance of a pharmacokinetic-pharmacodynamic(PK-PD) analysis is important to select the appropriate antimicrobial agent dosage. No information on the spread of dosage determination based on a PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept has spread among clinicians/practitioners responsible for primary care. Among the respondents, 34% of the physicians selected "know well" or "know to some extent", whereas 40% selected "do not know". Furthermore, 34% of the physicians reported that they considered the PK-PD concept "sufficiently" or "to some extent" when prescribing antimicrobial agents, whereas 42% did not consider this concept at all. The results suggest that the level of recognition or consideration shows no association with age. With respect to the daily dose most frequently used when prescribing levofloxacin tablets to adults without kidney dysfunction, 49% of the physicians reported "500 mg, once a day". When the level of consideration of the PK-PD theory for prescription was markedly lower, the number of prescriptions other than "500 mg, once a day" was greater. In the future, it may be important to educate non-infectious-disease-specialized clinicians/practitioners with respect to the PK-PD analysis and its practical application in order to promote the appropriate use of antimicrobial agents.

元の言語English
ページ(範囲)380-383
ページ数4
ジャーナルJapanese Journal of Chemotherapy
61
発行部数4
出版物ステータスPublished - 2013

Fingerprint

Anti-Infective Agents
Pharmacokinetics
Physicians
Prescriptions
Levofloxacin
Tablets
Primary Health Care
Kidney

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

これを引用

Are doctors aware of the PK-PD-based antimicrobial agent dosage and how to apply it? - Involving clinicians/practitioners. / Kizu, Junko; Terajima, Tomoko; Maezawa, Kayoko; Akita, Hironobu; Hori, Seiji.

:: Japanese Journal of Chemotherapy, 巻 61, 番号 4, 2013, p. 380-383.

研究成果: Article

Kizu, Junko ; Terajima, Tomoko ; Maezawa, Kayoko ; Akita, Hironobu ; Hori, Seiji. / Are doctors aware of the PK-PD-based antimicrobial agent dosage and how to apply it? - Involving clinicians/practitioners. :: Japanese Journal of Chemotherapy. 2013 ; 巻 61, 番号 4. pp. 380-383.
@article{87e84b5c45774686be849d0c1b2f99c8,
title = "Are doctors aware of the PK-PD-based antimicrobial agent dosage and how to apply it? - Involving clinicians/practitioners",
abstract = "Performance of a pharmacokinetic-pharmacodynamic(PK-PD) analysis is important to select the appropriate antimicrobial agent dosage. No information on the spread of dosage determination based on a PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept has spread among clinicians/practitioners responsible for primary care. Among the respondents, 34{\%} of the physicians selected {"}know well{"} or {"}know to some extent{"}, whereas 40{\%} selected {"}do not know{"}. Furthermore, 34{\%} of the physicians reported that they considered the PK-PD concept {"}sufficiently{"} or {"}to some extent{"} when prescribing antimicrobial agents, whereas 42{\%} did not consider this concept at all. The results suggest that the level of recognition or consideration shows no association with age. With respect to the daily dose most frequently used when prescribing levofloxacin tablets to adults without kidney dysfunction, 49{\%} of the physicians reported {"}500 mg, once a day{"}. When the level of consideration of the PK-PD theory for prescription was markedly lower, the number of prescriptions other than {"}500 mg, once a day{"} was greater. In the future, it may be important to educate non-infectious-disease-specialized clinicians/practitioners with respect to the PK-PD analysis and its practical application in order to promote the appropriate use of antimicrobial agents.",
keywords = "Antimicrobial agents, PK-PD, Questionnaire survey",
author = "Junko Kizu and Tomoko Terajima and Kayoko Maezawa and Hironobu Akita and Seiji Hori",
year = "2013",
language = "English",
volume = "61",
pages = "380--383",
journal = "Japanese Journal of Chemotherapy",
issn = "1340-7007",
publisher = "Japan Society of Chemotherapy",
number = "4",

}

TY - JOUR

T1 - Are doctors aware of the PK-PD-based antimicrobial agent dosage and how to apply it? - Involving clinicians/practitioners

AU - Kizu, Junko

AU - Terajima, Tomoko

AU - Maezawa, Kayoko

AU - Akita, Hironobu

AU - Hori, Seiji

PY - 2013

Y1 - 2013

N2 - Performance of a pharmacokinetic-pharmacodynamic(PK-PD) analysis is important to select the appropriate antimicrobial agent dosage. No information on the spread of dosage determination based on a PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept has spread among clinicians/practitioners responsible for primary care. Among the respondents, 34% of the physicians selected "know well" or "know to some extent", whereas 40% selected "do not know". Furthermore, 34% of the physicians reported that they considered the PK-PD concept "sufficiently" or "to some extent" when prescribing antimicrobial agents, whereas 42% did not consider this concept at all. The results suggest that the level of recognition or consideration shows no association with age. With respect to the daily dose most frequently used when prescribing levofloxacin tablets to adults without kidney dysfunction, 49% of the physicians reported "500 mg, once a day". When the level of consideration of the PK-PD theory for prescription was markedly lower, the number of prescriptions other than "500 mg, once a day" was greater. In the future, it may be important to educate non-infectious-disease-specialized clinicians/practitioners with respect to the PK-PD analysis and its practical application in order to promote the appropriate use of antimicrobial agents.

AB - Performance of a pharmacokinetic-pharmacodynamic(PK-PD) analysis is important to select the appropriate antimicrobial agent dosage. No information on the spread of dosage determination based on a PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept has spread among clinicians/practitioners responsible for primary care. Among the respondents, 34% of the physicians selected "know well" or "know to some extent", whereas 40% selected "do not know". Furthermore, 34% of the physicians reported that they considered the PK-PD concept "sufficiently" or "to some extent" when prescribing antimicrobial agents, whereas 42% did not consider this concept at all. The results suggest that the level of recognition or consideration shows no association with age. With respect to the daily dose most frequently used when prescribing levofloxacin tablets to adults without kidney dysfunction, 49% of the physicians reported "500 mg, once a day". When the level of consideration of the PK-PD theory for prescription was markedly lower, the number of prescriptions other than "500 mg, once a day" was greater. In the future, it may be important to educate non-infectious-disease-specialized clinicians/practitioners with respect to the PK-PD analysis and its practical application in order to promote the appropriate use of antimicrobial agents.

KW - Antimicrobial agents

KW - PK-PD

KW - Questionnaire survey

UR - http://www.scopus.com/inward/record.url?scp=84881354537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881354537&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84881354537

VL - 61

SP - 380

EP - 383

JO - Japanese Journal of Chemotherapy

JF - Japanese Journal of Chemotherapy

SN - 1340-7007

IS - 4

ER -