Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

Yoshihiko Suzuki, Motoaki Sano, Kentaro Hayashida, Ikuroh Ohsawa, Shigeo Ohta, Keiichi Fukuda

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The major side-effect of treatment with α-glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of α-glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H2 in the gastrointestinal tract. Acarbose, which is an α-glucosidase inhibitor, markedly increased H2 production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H2 acts as a unique antioxidant, and that when inhaled or taken orally as H2-dissolved water it ameliorates ischaemia-reperfusion injury and atherosclerosis development.

本文言語English
ページ(範囲)2157-2159
ページ数3
ジャーナルFEBS Letters
583
13
DOI
出版ステータスPublished - 2009 7 7

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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