Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells

S. B.H. Ko, S. Naruse, M. Kitagawa, H. Ishiguro, M. Murakami, T. Hayakawa

研究成果: Article

16 引用 (Scopus)

抜粋

The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced secretin-stimulated fluid secretion and increased the vascular resistance when the perfusion rate was held constant. In the isolated interlobular duct segments, AVP inhibited secretin-stimulated fluid secretion, indicating the direct inhibitory action of AVP on the duct cells. AVP affected neither the basal nor the secretin-induced cAMP productions, suggesting that AVP inhibits the fluid secretion at a point distal to the production of cAMP. AVP increased intracellular Ca2+ concentration ([Ca2+](i)) in the absence of extracellular Ca2+. When [Ca2+](i) was elevated by the application of thapsigargin, AVP caused a rapid decrease in [Ca2+](i). AVP seems to activate both Ca2+ release from intracellular stores and Ca2+ efflux across the plasma membrane, but its relation to the inhibition of fluid secretion remains to be clarified. It is concluded that AVP directly inhibits secretin-stimulated ductal fluid secretion in the guinea pig pancreas.

元の言語English
ページ(範囲)G48-G54
ジャーナルAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
277
発行部数1 40-1
出版物ステータスPublished - 1999 7 1
外部発表Yes

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

フィンガープリント Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Ko, S. B. H., Naruse, S., Kitagawa, M., Ishiguro, H., Murakami, M., & Hayakawa, T. (1999). Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells. American Journal of Physiology - Gastrointestinal and Liver Physiology, 277(1 40-1), G48-G54.