Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells

S. B.H. Ko, S. Naruse, M. Kitagawa, H. Ishiguro, M. Murakami, T. Hayakawa

研究成果: Article査読

16 被引用数 (Scopus)


The effects of arginine vasopressin (AVP) on pancreatic ductal secretion were studied in guinea pigs. In the isolated vascularly perfused pancreas, AVP reduced secretin-stimulated fluid secretion and increased the vascular resistance when the perfusion rate was held constant. In the isolated interlobular duct segments, AVP inhibited secretin-stimulated fluid secretion, indicating the direct inhibitory action of AVP on the duct cells. AVP affected neither the basal nor the secretin-induced cAMP productions, suggesting that AVP inhibits the fluid secretion at a point distal to the production of cAMP. AVP increased intracellular Ca2+ concentration ([Ca2+](i)) in the absence of extracellular Ca2+. When [Ca2+](i) was elevated by the application of thapsigargin, AVP caused a rapid decrease in [Ca2+](i). AVP seems to activate both Ca2+ release from intracellular stores and Ca2+ efflux across the plasma membrane, but its relation to the inhibition of fluid secretion remains to be clarified. It is concluded that AVP directly inhibits secretin-stimulated ductal fluid secretion in the guinea pig pancreas.

ジャーナルAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
1 40-1
出版ステータスPublished - 1999 7月

ASJC Scopus subject areas

  • 生理学
  • 肝臓学
  • 消化器病学
  • 生理学(医学)


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