Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

Taisuke Nakahama, Akihiro Kimura, Nam Trung Nguyen, Ichino Chinen, Hamza Hanieh, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto

研究成果: Article

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The contributions of aryl hydrocarbon receptor (Ahr) to the pathogenesis of rheumatoid arthritis have not been elucidated. Here, we show that Ahr deficiency ameliorated collagen-induced arthritis, a mouse model of RA. Collagen-immunized Ahr KO mice showed decreased serum levels of such proinflammatory cytokines as IL-1β and IL-6. The Th17 and Th1 cell populations in lymph nodes from these mice decreased and increased, respectively, whereas the percentage of regulatory T cells was unchanged. Interestingly, a lack of Ahr specifically in T cells significantly suppressed collagen-induced arthritis development, whereas Ahr deficiency in macrophages had no effect. These finding indicate that the development of experimental autoimmune arthritis depends on the presence of Ahr in T cells, and that Th1/Th17 balance may be particularly important for this process.

元の言語English
ページ(範囲)14222-14227
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
108
発行部数34
DOI
出版物ステータスPublished - 2011 8 23

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    Nakahama, T., Kimura, A., Trung Nguyen, N., Chinen, I., Hanieh, H., Nohara, K., Fujii-Kuriyama, Y., & Kishimoto, T. (2011). Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14222-14227. https://doi.org/10.1073/pnas.1111786108