Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production

Akihiro Kimura, Hiromi Abe, Sanae Tsuruta, Sayuri Chiba, Yoshiaki Fujii-Kuriyama, Takashi Sekiya, Rimpei Morita, Akihiko Yoshimura

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Aryl hydrocarbon receptor (AhR) is crucial for various immune responses. The relationship between AhR and infection with the intracellular bacteria Listeria monocytogenes (LM) is poorly understood. Here, we show that in response to LM infection, AhR is required for bacterial clearance by promoting macrophage survival and reactive oxygen species (ROS) production. AhR-deficient mice were more susceptible to listeriosis, and AhR deficiency enhances bacterial growth in vivo and in vitro. On the other hand, pro-inflammatory cytokines were increased in AhR-deficient macrophages infected with LM despite enhanced susceptibility to LM infection in AhR-deficient mice. Subsequent studies demonstrate that AhR protects against macrophage cell death induced by LM infection through the induction of the antiapoptotic factor, the apoptosis inhibitor of macrophages, which promotes macrophage survival in the setting of LM infection. Furthermore, AhR promotes ROS production for bacterial clearance. Our results demonstrate that AhR is essential to the resistance against LM infection as it promotes macrophage survival and ROS production. This suggests that the activation of AhR by its ligands may be an effective strategy against listeriosis.

本文言語English
論文番号dxt067
ページ(範囲)209-220
ページ数12
ジャーナルInternational immunology
26
4
DOI
出版ステータスPublished - 2014 4月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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