Arylmalonate decarboxylase—a highly selective bacterial biocatalyst with unknown function

Kenji Miyamoto, Robert Kourist

研究成果: Review article

4 引用 (Scopus)

抜粋

Bacterial arylmalonate decarboxylase (AMDase) shows high enantioselectivity and a broad substrate spectrum in the asymmetric synthesis of optically pure arylaliphatic carboxylic acids. The determination of the structure of AMDase has greatly extended the understanding of the catalytic mechanism of this unique cofactor-free decarboxylase and allowed the generation of tailor-made enzyme variants with improved catalytic properties. Despite this increase in knowledge and applicability, the natural role of the enzyme remains unknown. This mini-review summarizes the recent findings on the molecular mechanism and the synthetic application of the enzyme.

元の言語English
ページ(範囲)8621-8631
ページ数11
ジャーナルApplied Microbiology and Biotechnology
100
発行部数20
DOI
出版物ステータスPublished - 2016 10 1

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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