ASK1-signaling promotes c-Myc protein stability during apoptosis

Kohji Noguchi, Akiko Kokubu, Chifumi Kitanaka, Hidenori Ichijo, Yoshiyuki Kuchino

研究成果: Article査読

26 被引用数 (Scopus)

抄録

We previously reported that JNK is involved in the regulation of c-Myc-mediated apoptosis triggered by UV irradiation and anticancer drug treatment. Here we show that ASK1 is an upstream regulator for c-Myc-mediated apoptosis triggered by UV, and we found a direct role for Ser-62 and Ser-71 in the regulation of protein stability and function of c-Myc. The ASK1-JNK pathway enhanced the protein stability of c-Myc through phosphorylation at Ser-62 and Ser-71, which was required for c-Myc-dependent apoptosis by ASK1-signaling. Interestingly, ASK1-signaling attenuated the degradation of ubiquitinated c-Myc without affecting the ubiquitination process. Together, these findings indicate that the ASK1-JNK pathway promotes the proapoptotic activity of c-Myc by modulating c-Myc protein stability through phosphorylation at Ser-62 and Ser-71.

本文言語English
ページ(範囲)1313-1320
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
281
5
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「ASK1-signaling promotes c-Myc protein stability during apoptosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル