Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system

Hirokazu Kumazaki, Taro Muramatsu, Takashi X. Fujisawa, Masutomo Miyao, Eri Matsuura, Ken Ichi Okada, Hirotaka Kosaka, Akemi Tomoda, Masaru Mimura

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Background: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. Methods: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system - a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. Results: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 ± 0.28 vs 1.57 ± 0.15; p < 0.001) and allyl caproate (3.30 ± 0.23 vs 1.17 ± 0.08; p < 0.001). Conclusions: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment.

本文言語English
論文番号6
ジャーナルMolecular Autism
7
1
DOI
出版ステータスPublished - 2016 1 19

ASJC Scopus subject areas

  • 分子生物学
  • 発達神経科学
  • 発生生物学
  • 精神医学および精神衛生

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