Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study

Hirotsugu Mihara, Kentaro Shibayama, Hasan Jilaihawi, Yuji Itabashi, Javier Berdejo, Hiroto Utsunomiya, Robert J. Siegel, Raj R. Makkar, Takahiro Shiota

研究成果: Article

15 引用 (Scopus)

抄録

Objectives The purpose of this study was to determine which echocardiographic parameters, including holodiastolic flow reversal (HDFR) in the descending aorta, were useful for grading of post-procedural aortic regurgitation (PAR) after transcatheter aortic valve replacement (TAVR) using intraprocedural transesophageal echocardiography. Background Reliable assessment of PAR in a catheterization laboratory is essential for an optimal outcome after TAVR; however, such an assessment has not been determined. Methods Three hundred eighty patients who underwent TAVR with the Edwards (Irvine, California) balloon-expandable transcatheter heart valve were retrospectively assessed by intraprocedural transesophageal echocardiography. PAR was evaluated by 2-dimensional color Doppler and pulse-wave Doppler in the descending aorta. Using 2-dimensional color Doppler, we measured the cross-sectional area of the vena contracta, the circumferential extent at the aortic annular plane, the longitudinal jet length, and the jet extent (with a mosaic pattern in the left ventricular outflow tract) compared with the location of the tip of the anterior mitral leaflet (AML). Grading of PAR was determined using the following vena contracta cutoffs: mild ≤9 mm;be moderate 10 to 29 mm;be and severe ≥30 mm;be. Significant PAR was defined as at least moderate grade. Results All patients with consistent HDFR had significant PAR. By multivariable analysis, consistent HDFR and the jet extent beyond the tip of AML were independent predictors of significant PAR. Consistent HDFR and jet extent beyond the tip of AML predicted significant PAR with specificities of 100% and 97%, respectively. In contrast, patients with both negative HDFR and a jet extent of less than halfway to the tip of AML had no significant PAR, with 97% specificity. Conclusions The presence of consistent HDFR and jet extent beyond the tip of AML are indicative of significant PAR after TAVR.

元の言語English
ページ(範囲)993-1003
ページ数11
ジャーナルJACC: Cardiovascular Imaging
8
発行部数9
DOI
出版物ステータスPublished - 2015 9 1
外部発表Yes

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Aortic Valve Insufficiency
Transesophageal Echocardiography
Thoracic Aorta
Color
Transcatheter Aortic Valve Replacement
Heart Valves
Catheterization
Pulse

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

これを引用

Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study. / Mihara, Hirotsugu; Shibayama, Kentaro; Jilaihawi, Hasan; Itabashi, Yuji; Berdejo, Javier; Utsunomiya, Hiroto; Siegel, Robert J.; Makkar, Raj R.; Shiota, Takahiro.

:: JACC: Cardiovascular Imaging, 巻 8, 番号 9, 01.09.2015, p. 993-1003.

研究成果: Article

Mihara, H, Shibayama, K, Jilaihawi, H, Itabashi, Y, Berdejo, J, Utsunomiya, H, Siegel, RJ, Makkar, RR & Shiota, T 2015, 'Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study', JACC: Cardiovascular Imaging, 巻. 8, 番号 9, pp. 993-1003. https://doi.org/10.1016/j.jcmg.2015.02.029
Mihara, Hirotsugu ; Shibayama, Kentaro ; Jilaihawi, Hasan ; Itabashi, Yuji ; Berdejo, Javier ; Utsunomiya, Hiroto ; Siegel, Robert J. ; Makkar, Raj R. ; Shiota, Takahiro. / Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study. :: JACC: Cardiovascular Imaging. 2015 ; 巻 8, 番号 9. pp. 993-1003.
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title = "Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study",
abstract = "Objectives The purpose of this study was to determine which echocardiographic parameters, including holodiastolic flow reversal (HDFR) in the descending aorta, were useful for grading of post-procedural aortic regurgitation (PAR) after transcatheter aortic valve replacement (TAVR) using intraprocedural transesophageal echocardiography. Background Reliable assessment of PAR in a catheterization laboratory is essential for an optimal outcome after TAVR; however, such an assessment has not been determined. Methods Three hundred eighty patients who underwent TAVR with the Edwards (Irvine, California) balloon-expandable transcatheter heart valve were retrospectively assessed by intraprocedural transesophageal echocardiography. PAR was evaluated by 2-dimensional color Doppler and pulse-wave Doppler in the descending aorta. Using 2-dimensional color Doppler, we measured the cross-sectional area of the vena contracta, the circumferential extent at the aortic annular plane, the longitudinal jet length, and the jet extent (with a mosaic pattern in the left ventricular outflow tract) compared with the location of the tip of the anterior mitral leaflet (AML). Grading of PAR was determined using the following vena contracta cutoffs: mild ≤9 mm;be moderate 10 to 29 mm;be and severe ≥30 mm;be. Significant PAR was defined as at least moderate grade. Results All patients with consistent HDFR had significant PAR. By multivariable analysis, consistent HDFR and the jet extent beyond the tip of AML were independent predictors of significant PAR. Consistent HDFR and jet extent beyond the tip of AML predicted significant PAR with specificities of 100{\%} and 97{\%}, respectively. In contrast, patients with both negative HDFR and a jet extent of less than halfway to the tip of AML had no significant PAR, with 97{\%} specificity. Conclusions The presence of consistent HDFR and jet extent beyond the tip of AML are indicative of significant PAR after TAVR.",
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author = "Hirotsugu Mihara and Kentaro Shibayama and Hasan Jilaihawi and Yuji Itabashi and Javier Berdejo and Hiroto Utsunomiya and Siegel, {Robert J.} and Makkar, {Raj R.} and Takahiro Shiota",
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T1 - Assessment of Post-Procedural Aortic Regurgitation after TAVR An Intraprocedural TEE Study

AU - Mihara, Hirotsugu

AU - Shibayama, Kentaro

AU - Jilaihawi, Hasan

AU - Itabashi, Yuji

AU - Berdejo, Javier

AU - Utsunomiya, Hiroto

AU - Siegel, Robert J.

AU - Makkar, Raj R.

AU - Shiota, Takahiro

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objectives The purpose of this study was to determine which echocardiographic parameters, including holodiastolic flow reversal (HDFR) in the descending aorta, were useful for grading of post-procedural aortic regurgitation (PAR) after transcatheter aortic valve replacement (TAVR) using intraprocedural transesophageal echocardiography. Background Reliable assessment of PAR in a catheterization laboratory is essential for an optimal outcome after TAVR; however, such an assessment has not been determined. Methods Three hundred eighty patients who underwent TAVR with the Edwards (Irvine, California) balloon-expandable transcatheter heart valve were retrospectively assessed by intraprocedural transesophageal echocardiography. PAR was evaluated by 2-dimensional color Doppler and pulse-wave Doppler in the descending aorta. Using 2-dimensional color Doppler, we measured the cross-sectional area of the vena contracta, the circumferential extent at the aortic annular plane, the longitudinal jet length, and the jet extent (with a mosaic pattern in the left ventricular outflow tract) compared with the location of the tip of the anterior mitral leaflet (AML). Grading of PAR was determined using the following vena contracta cutoffs: mild ≤9 mm;be moderate 10 to 29 mm;be and severe ≥30 mm;be. Significant PAR was defined as at least moderate grade. Results All patients with consistent HDFR had significant PAR. By multivariable analysis, consistent HDFR and the jet extent beyond the tip of AML were independent predictors of significant PAR. Consistent HDFR and jet extent beyond the tip of AML predicted significant PAR with specificities of 100% and 97%, respectively. In contrast, patients with both negative HDFR and a jet extent of less than halfway to the tip of AML had no significant PAR, with 97% specificity. Conclusions The presence of consistent HDFR and jet extent beyond the tip of AML are indicative of significant PAR after TAVR.

AB - Objectives The purpose of this study was to determine which echocardiographic parameters, including holodiastolic flow reversal (HDFR) in the descending aorta, were useful for grading of post-procedural aortic regurgitation (PAR) after transcatheter aortic valve replacement (TAVR) using intraprocedural transesophageal echocardiography. Background Reliable assessment of PAR in a catheterization laboratory is essential for an optimal outcome after TAVR; however, such an assessment has not been determined. Methods Three hundred eighty patients who underwent TAVR with the Edwards (Irvine, California) balloon-expandable transcatheter heart valve were retrospectively assessed by intraprocedural transesophageal echocardiography. PAR was evaluated by 2-dimensional color Doppler and pulse-wave Doppler in the descending aorta. Using 2-dimensional color Doppler, we measured the cross-sectional area of the vena contracta, the circumferential extent at the aortic annular plane, the longitudinal jet length, and the jet extent (with a mosaic pattern in the left ventricular outflow tract) compared with the location of the tip of the anterior mitral leaflet (AML). Grading of PAR was determined using the following vena contracta cutoffs: mild ≤9 mm;be moderate 10 to 29 mm;be and severe ≥30 mm;be. Significant PAR was defined as at least moderate grade. Results All patients with consistent HDFR had significant PAR. By multivariable analysis, consistent HDFR and the jet extent beyond the tip of AML were independent predictors of significant PAR. Consistent HDFR and jet extent beyond the tip of AML predicted significant PAR with specificities of 100% and 97%, respectively. In contrast, patients with both negative HDFR and a jet extent of less than halfway to the tip of AML had no significant PAR, with 97% specificity. Conclusions The presence of consistent HDFR and jet extent beyond the tip of AML are indicative of significant PAR after TAVR.

KW - aortic stenosis

KW - paravalvular regurgitation

KW - transcatheter aortic valve replacement

KW - transesophageal echocardiography

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