Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Toshio Kojima, Hidehiko Kamei, Tomoyuki Aizu, Yasumichi Arai, Michiyo Takayama, Susumu Nakazawa, Yoshinori Ebihara, Hiroki Inagaki, Yukie Masui, Yasuyuki Gondo, Yoshiyuki Sakaki, Nobuyoshi Hirose

研究成果: Article査読

93 被引用数 (Scopus)

抄録

Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A. We investigated the possible association of each gene locus and longevity by haplotype-based association analyses using 18 SNPs from public databases and the published literature. One INSR haplotype, which was comprised of 2 SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls.

本文言語English
ページ(範囲)1595-1598
ページ数4
ジャーナルExperimental Gerontology
39
11-12 SPEC. ISS.
DOI
出版ステータスPublished - 2004 11

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 分子生物学
  • 遺伝学
  • 内分泌学
  • 細胞生物学

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