Association between antidepressant side effects and functional impairment in patients with major depressive disorders

Toshiaki Kikuchi, Takefumi Suzuki, Hiroyuki Uchida, Koichiro Watanabe, Masaru Mimura

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Patients with depression may not well be aware of antidepressant adverse events (AEs); however, no studies have assessed how these AEs affect their daily function. Therefore, to evaluate the relationship between the quality of AEs and functional impairment, we studied 482 outpatients with depressive disorders who were not receiving any antidepressant treatment prior to the baseline visit and started it thereafter in usual clinical settings. The Quick Inventory for Depressive Symptomatology Self-Report Japanese version and antidepressant AEs for subjective assessment (antiAS) were performed at baseline and 10 days after antidepressant initiation (i.e. second visit). Functional impairment was evaluated with the Sheehan Disability Scale (SDS) on the second visit. As a result, the SDS was positively associated with the number of AEs (β=0.089, p=0.022) in multiple linear regression analysis (adjusted R2=0.357, p<0.001). Subjects who experienced vertigo, nausea and insomnia had significantly more functional impairment than those who did not. Additionally, the number of severe AEs (β=0.151, p<0.001) was associated with a higher SDS score, and those AEs with a negative causal attribution to antidepressants in the antiAS significantly affected the SDS (β=0.105, p=0.008). AEs of antidepressants should be carefully monitored since they could negatively affect their daily function.

本文言語English
ページ(範囲)127-133
ページ数7
ジャーナルPsychiatry Research
210
1
DOI
出版ステータスPublished - 2013 11 30

ASJC Scopus subject areas

  • 精神医学および精神衛生
  • 生物学的精神医学

フィンガープリント

「Association between antidepressant side effects and functional impairment in patients with major depressive disorders」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル