Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects

Yutaka Ono, Hiroshi Manki, Kimio Yoshimura, Taro Muramatsu, Hiroko Mizushima, Susumu Higuchi, Gohei Yagi, Shigenobu Kanba, Masahiro Asai

研究成果: Article査読

126 被引用数 (Scopus)

抄録

This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Japanese version of Cloninger's Temperament and Character Inventory. The Novelty Seeking subscale of Exploratory Excitability had a significant association with long alleles of the polymorphic exon III repeat sequence of D4DR. Our results suggest that there is an association between long alleles of the polymorphic exon III repeat sequence of D4DR and the personality traits of the Novelty Seeking subscale of Exploratory Excitability, regardless of racial differences in the frequencies of D4DR exon III repeat polymorphism.

本文言語English
ページ(範囲)501-503
ページ数3
ジャーナルAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
74
5
DOI
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 遺伝学(臨床)
  • 精神医学および精神衛生
  • 細胞および分子神経科学

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